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PMID: 31155494 Autophagy XIAP-ULK1-Mediated mitophagy modulates carnitine metabolism to mitigate diabetic kidney disease

Rotate to avoid tissue buildup

Peschanski et al

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Drugs with a Vd value of less than 0.3 L/kg are predominantly confined to the ECF, whereas drugs with a Vd value of greater than 1 L/kg are highly lipid soluble and tend to distribute out of the extracellular fluid and into tissue compartments (Box 4-1)

10.1016/j.phymed.2022.154435 160 WangR.YuX